Abstract A simple, rapid and precise reverse phase high performance liquid chromatography method was developed for the analysis of Atvimopin Chromatographic separation of Atvimopin was performed by using a waters C18 column (250 x 4.6mm, 5 µm) as stationary phase with a mobile phase comprising of Methanol:Acetonitrile80:20 (v/v/v) at a flow rate of 1.0ml/min and…
Abstract A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Tadalafil tablet dosage form. Isocratic elution at a flow rate of 1.3ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: Acetonitrile 65:35 v/v. The UV detection…
Abstract The object of the present study is to carry out the Physico – Chemical analysis of well and bore well water samples from fourteen sampling stations ofLaksminarasapuram (Rural area) in the vicinity of Anaparthi mandal , East godavariDistrict(AP) on 12th of every month ( for a period of six months) from September 2011 to…
Abstract Asimple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Vismodegib in tablet dosage form. Isocratic elution at a flow rate of 1 ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: water: Acetonitrile 55:25:20 % (V/V)….
Abstract A HPLC method was developed and validated for simultaneous determination of Terpineol, Limonene, α-Terpinenein Black cardamom using a Hypersil bds C18column (250 mm×4.6 mm, 5 μm) with the mobile phase consisting of Methanol and 0.1% triethylamine,0.05M KH2PO4used as mobile phase in the ration of 45%,10%,45% The linear ranges of three compounds were determined and method…
Abstract An improved synthesis of N-substituted imides can be achieved from the reaction of anhydrides (phthalic, maleic & succinic.) with pre-melted anilines by grinding at room temperature in the absence of solvents. The advantages of this method are good yields, shorter reaction times, low cost and matching with green chemistry protocols.
Abstract An efficient one pot green synthesis of (Z)-N-5-(benzylidene/substituted benzylidene) -2-benzamido–3- (methyl/phenyl)-6-oxo-1, 2, 5, 6-tetrahydro-1, 2, 4-triazines has been developed in good yields and tested for their anti-bacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus Subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus Subtillis compared to…
Abstract Pyrazinamide is an antituberculosis agent. It works by killing or preventing the growth of certain bacteria that cause tuberculosis. HPLC and UV method was employed for the estimation of Pyrazinamide in pharmaceutical formulations. A mixture of Methanol: Water in the ratio of 80:20 (v/v/v) at a pH of 4.8 in isocratic conditions and separation…
Abstract Risperidone is a potent antipsychotic drug which is mainly used to treat schizophrenia and schizoaffective disorder. A new isocratic HPLC method was developed for analysis in formulations. The developed method was validated according to ICH guidelines. The method was developed with the mobile phase 0.1% OPA: Methanol:Acetonitrile in the ratio of 60:25:15(V/V/V). In this method the back pressure was…
Abstract Rosmarinusofficinalis is one among the phenomenon herb. This wonder herb has numerous health benefits which sometimes outshined. As a health contributor rosemary has attracted many herbal manufacturer as well as suppliers. Its different forms such as oil, powder, cream etc gives an extra edge to this herb in comparison to others. The present review…