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Genomics and Genetics of Wolbachia: A review

ByFirepubs

Abstract Wolbachiaare one of the most ubiquitous obligate intracellular maternally inherited bacteria that have been found in several arthropod groups.Wolbachiabehave as areproductive parasite by manipulating host reproduction to enhance their vertical transmission. Their reproductive modification and cytoplasmic incompatibility (CI) has received attention for use in applied strategies targeting economically important insect pests and disease vectors….

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HPLC and UV Spectrophotometric Estimation of Pyrazinamide in Pharmaceutical Formulations

ByFirepubs

Abstract Pyrazinamide is an antituberculosis agent. It works by killing or preventing the growth of certain bacteria that cause tuberculosis. HPLC and UV method was employed for the estimation of Pyrazinamide in pharmaceutical formulations. A mixture of Methanol: Water in the ratio of 80:20 (v/v/v) at a pH of 4.8 in isocratic conditions and separation…

Incidence of cancer in breast lumps seen in a private rural surgical practice in South Eastern Nigeria

ByFirepubs

Abstract Background: There is increasing awareness and anxiety about breast cancer amongst rural women who present at our practice located in an area of limited resources. Aims:  To determine the incidence of breast cancer in patients presenting in our service with  breast lumps .                Patients and methods: This is a retrospective work, reviewing the pathology…

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Method development and validation of an Isocratic High pressure Liquid chromatography technique for analysis of Risperidone in Bulk drug and Formulation

ByFirepubs

Abstract Risperidone is a potent antipsychotic drug which is mainly used to treat schizophrenia and schizoaffective disorder. A new isocratic HPLC method was developed for analysis in formulations. The developed method was validated according to ICH guidelines. The method was developed with the mobile phase 0.1% OPA: Methanol:Acetonitrile in the ratio of  60:25:15(V/V/V). In this method the back pressure was…

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Pharmaco-Economical And Nutritional Overview Of Rosemary

ByFirepubs

Abstract Rosmarinusofficinalis is one among the phenomenon herb. This wonder herb has numerous health benefits which sometimes outshined. As a health contributor rosemary has attracted many herbal manufacturer as well as suppliers. Its different forms such as oil, powder, cream etc gives an extra edge to this herb in comparison to others. The present review…

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Dissolution Profile of Theophylline Extended Release Caplets Based On Metolose 90 SH – 4000SR With Accelerated Stability Study

ByFirepubs

Abstract To avoid consume theophylline oftenly, we need an extended release dosage form to maintain the therapeutic dose on the blood plasma for a long interval time. The most common dosage form in the market is coated tablet, but that needs a long procedure and quite expensive to be produced. Recently, there is a brand…

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The Legal System of Pharmaceutical Patents in Brazil

ByFirepubs

Abstract This study aims to discuss the criteria adopted by the Brazilian legislation on the patentability of pharmaceutical products at the National Institute of Industrial Property, as well as the obligation to submit the application to a prior consent from the National Health Surveillance Agency, due to the great social importance of the theme of…

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Validated UV and Visible Spectrophotometric Methods for the quantification of Haloperidol in Pharmaceutical dosage forms

ByFirepubs

Abstract Simple and cost effective UV and Visible spectroscopic methods were described for the estimation of Haloperidol in  Phamaceutical dosage forms. Visible method was based on the formation of organic solvent extractable ion association complex with ARS dye.  In both methods the solutions showed maximum absorption at 248nm, 495nm; also obeyed Beer’s law in the…

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Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of Telmisartan and Hydrochlorothiazide in Plasma

ByFirepubs

Abstract A rapid, sensitive and selective analytical Liquid chromatography tandem mass spectrometrymethod was developed and validated for the determination Telmisartan and Hydrochlorothiazidein human plasma. Liquid-liquid extraction was used for sample preparation and analysis, followed by liquid chromatography tandem spectrometric analysis and an electrospray-ionization interface. Compounds were analyzed on a Aquasil-C18 (250×4.6mm×5µm) column with the mobile…

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Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Avibactam and Ceftazidime in Bulk drug and injection dosage Form

ByFirepubs

Abstract The aim of the present work was to develop simple, shorter and effective HPLC method with UV detection (255 nm) and subsequent validation for the simultaneous determination of Avibactam and Ceftazidime in marketed tablet samples. The mobile phase consisted of 1% OPA: Acetonitrile 55:45 (v/v) [pH 5.5], an isocratic elution at a flow rate…