Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Denosumab in tablet dosage form. Isocratic elution at a flow rate of 1.0ml/min was employed on a symmetry C18 (250×4.6mm, 5μm in particle size) at ambient temperature. The mobile phase consisted of methanol: water: O.P.A 90:10:01 (V/V/V)….
Abstract There are several routes of drug administration like oral, trans-dermal, parenteral, rectal, ocular, introvaginal, nasal etc. Amongst them nasal drug delivery shows great impact. Extensive efforts have done to target a drug in a particular region of body for long period of time not only for local targeting of drugs but also for control…
Abstract A series of vanillin derivatives (1-3) were synthesized and their proposed structure was established by elemental analyses, FTIR and 1H-NMR spectral. In this paper we employed A 3D pharmacophore model based on selected ten established NA inhibitors as training set with diverse molecular structures and performed docking simulation using PDB-2HU0 to observe the ligand-protein…
Abstract The objective of this work was to develop sustained release tablets (Once in a day) of highly water soluble Tramadol HCl using hydrophilic polymers (HPMC K100M, HPMC K15M, HPMC K 4M) as cost effective, non toxic easily available and suitable hydrophilic matrix system. Sustained release tablet of Tramadol HCl (dose 200mg) were produced by…
Oral route is most common and preferred route from efficacy and safety point of view.
Simple, rapid, sensitive and economical spectrophotometeric procedures for the determination of anticholinergic drug Biperiden hydrochloride
The present research work discusses the development of a UV spectrophotometric method for Voriconazole.
Motion sickness is a common problem which is evoked in a susceptible person, when they are subjected to the movements
To investigate the effect of Nomaphila stricta(Family: acanthaceae) root extracts on diabetic related atheroclerosis.
A highly sensitive isocratic reverse phase high performance liquid chromatographic method was developed