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Development and Validation of New Analytical Method for Voriconazole for Injection by Using Uv-Spectrophotometer

Abstract

The present research work discusses the development of a UV spectrophotometric method for Voriconazole. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Voriconazole in pharmaceutical dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 255nm. The percentage recovery of Voriconazole was in the 99.61-101.63%. Beers law was obeyed in the concentration range of 10-25μg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.026x-0.0036 with correlation coefficient of 0.99953 was obtained. Validation was performed as ICH guidelines for Specificity,linearity, accuracy, precision.

Issue

IJAPSBS vol 1 (2012)

Article Subject:

Pharmacy

Keywords:

Voriconazole, uv spectrophotometric method

Download PDF:

ijapsbs-1.3.240-247

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