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Isolation of Actinomycetes from Marine Soil Collected from Nizampatnam Port Area

Abstract ACTINOMYCETES are micro organisms with high medicinal activities. In many places research work going on inthis organism. So many Microbiologists isolated new and existed species from different environment soil. In order toidentification and isolation of Actinomycetes we are selected marine soil from Nazam patnam Port, Guntur Distric, Andrapradesh, India

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RP-HPLC Method Development and Validation for the Analyisis of Ezogabine in Pharmaceutical Dosage Forms

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for assay of Ezogabine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:Water:Acetonitrile 30:50:20 (v/v/v). The UV detection wavelength was at…

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RP‐HPLC Method Development And Validation for the Analysis of Vendetanib in Phramaceutical Dosage Forms

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of VENDETANIB in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Acetonitrile:ethylalchol:NH4H2PO4 60:25:15(v/v/v).The UV detection wavelength was at 219nm. Linearity…

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Identification of Anti‐Diabetic Activity of Strychnous Nuxvomica Roots in Invivo Conditions

Abstract Strychnous nuxvomica is a medicinal plant with many chemical constituents like strychnine, brucine, indole alkaloids etc. This study was design to investigate the effect of aqueous methanol extract of nuxvomica roots, on various biological parameters in diabetes induced rabbits. The effect of crude nuxvomica root and its organic extracts on blood glucose level of…

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New Spectrophotometric Method for Analysis of Erubulin in Pharmaceutical Dosage Forms

Abstract A simple, sensitive and economical spectrophotometric method has been developed for the determination of Erubulin in commercial dosage forms.In this method ferric chrloride and Potassium ferricyanide were used for the colour development.The maximum absorbance was found at 410nm against the reagent blank treated similarly.Statistical analysis proves that the proposed method is reproducible and selective…

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Validated RP – HPLC Method for the Estimation of Denosumab in Formulation

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Denosumab in tablet dosage form. Isocratic elution at a flow rate of 1.0ml/min was employed on a symmetry C18 (250×4.6mm, 5μm in particle size) at ambient temperature. The mobile phase consisted of methanol: water: O.P.A 90:10:01 (V/V/V)….

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A Review on Application of Natural Bioadhesive Polysaccharides for Intranasal Drug Delivery

Abstract There are several routes of drug administration like oral, trans-dermal, parenteral, rectal, ocular, introvaginal, nasal etc. Amongst them nasal drug delivery shows great impact. Extensive efforts have done to target a drug in a particular region of body for long period of time not only for local targeting of drugs but also for control…

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Pharmacophore Modelling, Docking and Biological Evaluation of Vanillin Derivatives as Neuraminidase Inhibitors

Abstract A series of vanillin derivatives (1-3) were synthesized and their proposed structure was established by elemental analyses, FTIR and 1H-NMR spectral. In this paper we employed A 3D pharmacophore model based on selected ten established NA inhibitors as training set with diverse molecular structures and performed docking simulation using PDB-2HU0 to observe the ligand-protein…

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The Physicochemical Quality of Commercial Ice – A Case Study of Urban and Rural Settlement

Abstract The quality of commercial ice has been investigated by examination of physical, chemical characteristics. Targetsamples were those which were used in food in retail businesses such as Fruit juices, cold drinks, hotels etc for direct human consumption. A total of 10 Samples were collected from the transported vehicles which carry ice from manufacturing plants…

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Formulation, Optimization and In-Vitro Evaluation of Sustained Release Matrix Tablets of Tramadol Hydrochloride

Abstract The objective of this work was to develop sustained release tablets (Once in a day) of highly water soluble Tramadol HCl using hydrophilic polymers (HPMC K100M, HPMC K15M, HPMC K 4M) as cost effective, non toxic easily available and suitable hydrophilic matrix system. Sustained release tablet of Tramadol HCl (dose 200mg) were produced by…