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LCMS Method Devlopment and Validation of Paliperidone in Formulation Dosage

Abstract A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Paliperidone tablet dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: Acetonitril: Water 60: 10: 30 v/v,…

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A Novel RP-HPLC Method for the Determination of Capecitabine in Pharmaceutical Drug Products

Abstract A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Capecitabine in tablet dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol:Water 80: 20 v/v, (PH 4.9)….

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A Novel RP-HPLC Method for the Quantification of Tadalafil in Formulations

Abstract A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Tadalafil tablet dosage form. Isocratic elution at a flow rate of 1.3ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: Acetonitrile 65:35 v/v. The UV detection…

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RP-HPLC Method for the Quantification of Vismodegib in Formulations

Abstract Asimple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Vismodegib in tablet dosage form. Isocratic elution at a flow rate of 1 ml/min was employed on a symmetry Chromosil C18 (250×4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: water: Acetonitrile 55:25:20 % (V/V)….

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Method development and validation of an Isocratic High pressure Liquid chromatography technique for analysis of Risperidone in Bulk drug and Formulation

Abstract Risperidone is a potent antipsychotic drug which is mainly used to treat schizophrenia and schizoaffective disorder. A new isocratic HPLC method was developed for analysis in formulations. The developed method was validated according to ICH guidelines. The method was developed with the mobile phase 0.1% OPA: Methanol:Acetonitrile in the ratio of  60:25:15(V/V/V). In this method the back pressure was…

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RP-HPLC Method Development and Validation for the Analyisis of Ezogabine in Pharmaceutical Dosage Forms

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for assay of Ezogabine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:Water:Acetonitrile 30:50:20 (v/v/v). The UV detection wavelength was at…

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Validated RP – HPLC Method for the Estimation of Denosumab in Formulation

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Denosumab in tablet dosage form. Isocratic elution at a flow rate of 1.0ml/min was employed on a symmetry C18 (250×4.6mm, 5μm in particle size) at ambient temperature. The mobile phase consisted of methanol: water: O.P.A 90:10:01 (V/V/V)….