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Method development and validation of an Isocratic High pressure Liquid chromatography technique for analysis of Risperidone in Bulk drug and Formulation

ByFirepubs

Abstract Risperidone is a potent antipsychotic drug which is mainly used to treat schizophrenia and schizoaffective disorder. A new isocratic HPLC method was developed for analysis in formulations. The developed method was validated according to ICH guidelines. The method was developed with the mobile phase 0.1% OPA: Methanol:Acetonitrile in the ratio of  60:25:15(V/V/V). In this method the back pressure was…

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RP-HPLC Method Development and Validation for the Analyisis of Ezogabine in Pharmaceutical Dosage Forms

ByFirepubs

Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for assay of Ezogabine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:Water:Acetonitrile 30:50:20 (v/v/v). The UV detection wavelength was at…