Validated UV and Visible Spectrophotometric Methods for the quantification of Haloperidol in Pharmaceutical dosage forms

Simple and cost effective UV and Visible spectroscopic methods were described for the estimation of Haloperidol in  Phamaceutical dosage forms. Visible method was based on the formation of organic solvent extractable ion association complex with ARS dye.  In both methods the solutions showed maximum absorption at 248nm, 495nm; also obeyed Beer’s law in the concentration range of 25-250 μg/mL and 2-14 μg/mL for UV and ARS methods respectively. The absorbance was found to increase linearly with increasing concentration of Haloperidol with correlation coefficient of 0.995 and 0.992 for both methods respectively. The optimum experimental parameters for the reaction have been studied. The validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed methods were successfully applied for the determination of Haloperidol in pharmaceutical formulations.