A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Iloperidone tablet dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a Zodiac C18 (250x4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted Methanol: Acetonitrile 80:20 v/v. The UV detection wavelength was 210nm and 20µl sample was injected. The retention time for Iloperidone was 7.1min. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated as per the ICH guidelines. The method was successfully applied for routine analysis of Iloperidone tablet dosage form and bulk drug.
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