Hepatoprotective Role of Yucca Rupicola Texas Yucca Extract Against Ccl4 Induced Hepatotoxicity in Rats

Yucca rupicola texas yucca commonly known as soap weed and Family- Aspargaceae. It is a stermsless or rising of stature of small trees and trunk short. The whole plant of Yucca rupicola texas yucca is used for ulcer and rheumatoid arthritis . To investigate the hepatoprotective activity and acute oral toxicity of extract of whole plant of Yucca rupicola texas yucca (RTY) in male Wistar albino rats by using CCl4 induced hepatoptoxicity. The RTY at doses of 200 and 400mg/kg, p.o and the standard drug Silymarin (100mg/kg, p.o) were administered three times at 12h intervals and then CCl4 (1ml/kg) was administered to all the groups except normal control for 2 days. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, ALP, γ-GT, TP
and total bilirubin along with histopathological studies were observed after 36h of CCl4 treatment. The RTY at the doses of 200 and 400mg/kg inhibited CCl4 induced liver toxicity in Wistar albino rats as assessed by the biochemical changes and histopathological studies. The aqeous extract of whole plant of Yucca rupicola texas yucca afforded significant protection against CCl4 induced hepatocellular injury