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The heart is a muscular organ found in all vertebrates that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. Advanced glycation end products contribute to the pathogenesis of atherosclerosis complications. T-Colostrol which is the extract of Musa paradisiaca belongs to the family of Musaceae along with Ferrous oxide and Black salt were analyzed and tested for anti-atherosclerotic activity in vivo using hypercholesterolemic albino rats. T-Colostrol (at final 0.5mg/mL) had the strongest anti-glycation and antiatherosclerotic activity in this study. T-Colostrol had the strongest inhibition of activity against low-density lipoprotein (LDL) and potent cholesteryl ester transfer protein (CETP) inhibitory activity in a concentration-dependent
manner. They exhibited hypolipidemic activity in a hypercholesterolemic albino rat’s model; the T-Colostrol -treated group had a 68% and 80% decrease in serum cholesterol and TG levels, respectively. Hydrophilic ingredients of TColostrol showed potent activities to suppress the incidence of atherosclerosis via strong inhibition of CETP, and hypolipidemic activity. These results suggest the potential to develop a new functional dietary agent to treat chronic metabolic diseases, such as hyperlipidemia.

Anti-atherosclerotic activity
Musa paradisiacal
low-density lipoprotein.
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